Preliminary Notes

نویسنده

  • Richard Katz
چکیده

Bombesin and eledoisin are both biologically active peptides derived from amphibian skin. They have been established to affect a variety of centrally mediated physiological processes in mammals (e.g. DeCaro, Micossi , Venturi, Brancati and Scarnati, 1974; Rivier and Brown, 1978), and may therefore be similar to or identical with endogenous mammalian neuropeptides. One prominent class of peptide mediated effects in mammals is compulsive grooming, and peptides as diverse as opioid peptides, ACTH deriyed peptides and substance P derived peptides have previoisly been ‘shown to elicit this behavior (Dunn, Green and Isaacson, 1979; m3, 1970; Gi spen, Reith, Schotman, Weigant , Zwiers and DeWeid, 1977; Katz, 19791. Other treatments known to increase. grooming include systemic morphine, under selected conditions (e.g. Fog, 19701 and stress (Katz and Roth, 1979). Bombesin and eledoisin are distinct from the above and heretofore they have not been systematically examined for their ability to affect grooming. The present report therefore examined both compounds’ effects upon this behavior.

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تاریخ انتشار 2002